Usually bone density shots refer to the infusion of zoledronate drug for anti-osteoporosis treatment. Zoledronate is a bone resorption inhibitor, a new anti-osteoporosis drug that is more effective and has a lower incidence of adverse effects than the first-generation drugs, and improves bone density more significantly. Zoledronate is very effective in reducing fractures in critical areas such as vertebrae, hip and distal ulna-radius. Zoledronate has a prominent role in reducing the average cost of treatment and improving the quality of life. Moreover, zoledronate is infused once a year, and patient compliance is better, resulting in a better anti-osteoporosis effect. However, it should be noted that zoledronate sodium also has acute adverse reactions, including fever, muscle pain, bone pain and other acute flu-like symptoms, and even gastrointestinal reactions, dyspnea, edema, renal insufficiency, skin rash, liver injury and other symptoms. It is necessary to pay attention to the management of adverse reactions, strengthen the examination before the use of drugs in order to exclude contraindications; do a good job in the management of infusion, control the low rate; do a good job in the observation of symptoms, timely adjustment of medication, while complying with the doctor’s instructions, the application of medication to prevent adverse reactions; the emergence of adverse reactions, do a good job in pacifying the patient, to reduce the psychological burden of the patient.