Urethral irritation after taking medication is mainly considered to be related to improper use of medication, adverse drug reactions and other factors. 1. Improper use of drugs: in the treatment of urethritis, cystitis and other diseases, the amount of medication is not enough or not for the causative organisms, may delay the condition, resulting in exacerbation of the condition, and then the phenomenon of more irritation of the urethra. 2. Adverse drug reactions: after the application of drugs, adverse drug reactions may also occur in the urethra more irritation. 3. Other factors: such as urethral stones, urethral tumors and other diseases, after the use of drugs, may also appear more irritation phenomenon. If the above symptoms occur, it is necessary to go to the urology department in a timely manner, after diagnosing the cause of the disease, and follow the guidance of the specialist for treatment.