Swollen tongue with teeth marks may be tongue adaptive hypertrophy, tongue amyloidosis or tongue tumor, which requires corresponding prosthetic, pharmacological or surgical treatment. 1. Adaptive hypertrophy of the tongue. Tongue enlargement with teeth marks may be caused by adaptive hypertrophy of the tongue due to long-term loss of teeth in the oral cavity, and the size of the tongue will return to normal after denture repair of the missing part. 2. Tongue amyloidosis. Protein metabolism disorders can cause tongue amyloidosis, tongue enlargement, teeth marks on both sides, tongue pain, nodular protuberance, generally no specific treatment, mainly oral prednisone, melphalan, colchicine and other drugs. 3. Tumor of tongue body. Tongue hypertrophy may be a tumor of the tongue, teeth up and down bite can bite to the hypertrophy of the tongue appeared teeth marks, generally consider surgical resection after examination. The treatment plan for tongue enlargement with teeth marks needs to go to the hospital first to check the cause of the targeted treatment, the medication needs to follow the doctor’s prescription.