Applying Cephalosporin III followed by Cephalosporin II has the potential to be effective. But if the use is not standardized, there is a possibility that the bacteria will develop drug resistance faster. So if it is an irregularity in the use of medication, changing antibiotics so frequently, not using too much antibiotic each time, there is a risk that it will not be effective. Take the risk of making the bacteria resistant in this way and thus also take the risk of treatment failure. If you have been using Cephalosporin III for a sufficient period of time, then switching to Cephalosporin II at this point works in most cases. But it also depends on what kind of bacteria, each kind of bacteria to different cephalosporins, they are not the same degree of sensitivity. If it is gram-negative bacilli, Cephalosporin III is more effective in killing them, and if you switch to Cephalosporin II, the efficiency of killing them will be reduced on the whole. However, in the case of gram-positive cocci, the bactericidal efficacy of cephalosporin II may be enhanced after switching to the second-generation cephalosporin.