Rectal cancer with localized bone destruction can be treated promptly by surgery, radiotherapy, chemotherapy and targeted therapy. 1. Surgery: For rectal cancer with bone metastasis, local surgical resection is feasible when there is a chance of surgery, and then radiotherapy and chemotherapy are supplemented after surgery. 2. Radiotherapy: it is a therapy that uses the energy released by high-energy rays to kill tumor cells, and local radiotherapy can be used to eliminate bone metastasis lesions. 3. Chemotherapy: It is a systemic therapy that uses chemotherapeutic drugs such as 5-fluorouracil and capecitabine to reach the lesions with the bloodstream, and it can often be combined with radiotherapy and other co-treatments. 4. Targeted therapy: It is a precise therapy for specific mutation targets with fewer side effects. Commonly used drugs include bevacizumab and abciximab. Rectal cancer patients with localized bone destruction need to give the best treatment plan through the comprehensive assessment of the condition by clinical attending doctors and actively cooperate with the treatment. All the above drugs should be applied under the guidance of doctors.