In the process of taking antihypertensive drugs for hypertensive patients, both valsartan and irbesartan are angiotensin II receptor antagonists that can be used as options, and there is no significant difference between the two in terms of lowering blood pressure, and there is no significant difference in terms of target organ damage, which can do the protection related to target organ function or organ damage of heart, brain and kidney. Antihypertensive drugs can be chosen from valsartan or irbesartan. The choice of antihypertensive drug is determined by the blood pressure level and the type of target organ damage. For blood pressure levels, grade 2 or higher hypertension, the starting combination of two or more different mechanisms of antihypertensive drugs is recommended for treatment, either a combination of valsartan and diphenhydramine or a combination of valsartan and diuretics. For target organ damage protection, valsartan can comprehensively protect patients with cardiovascular disease throughout, while irbesartan has a superior role for patients with renal insufficiency in terms of urine protein reduction, etc.