After strenuous exercise, the body will produce a lot of heat, which stimulates the central nervous system of the brain, as well as the peripheral nerves of the body, producing too much acetylcholine, which can cause the peripheral nerves to release sensitizing substances, such as histamine, interleukin and some other substances. These substances are sensitizers that may cause patients to develop erythema, papules, and wheals, accompanied by itching and tingling, which is the common clinical condition of cholinergic urticaria. Therefore, for this group of people, it is recommended that patients need to suspend exercise, peripheral erythema, papules and wheals, as well as itching and tingling sensation will soon be relieved. If recurrent episodes, this time you need to go to the dermatology department, under the guidance of the doctor oral compound glycyrrhizin tablets and ketotifen tablets. Meanwhile, on topical medication, fluticasone propionate ointment and urea Vitamin E cream can be applied mixed topically, and patients are instructed to avoid strenuous exercise.