Numbness and soreness of the right leg may be caused by prolonged sedentary activities, pyriformis lesion, lumbar spine disease, etc. It can be relieved by physical therapy, medication and surgery. 1. Prolonged sedentary: prolonged sedentary, standing, wrong sitting posture, etc., the limbs are in a state of compression for a long time, it will be easy to feel numbness and soreness. You can elevate your legs, walk less, avoid drooping legs for too long, and you can also relieve numbness and soreness of the right leg through physical therapy such as localized microwave therapy and intermediate-frequency electrotherapy. 2. Piriformis lesion: the numbness and swelling of the right leg of the patient may be caused by the spasm of the piriformis muscle, resulting in sciatic nerve compression, leading to ischemia and hypoxia of the sciatic nerve, and the nerve conduction function is changed. Sciatic nerve in the knee joint divided peroneal nerve, direct innervation of the foot skin sensation, can cause numbness in the foot symptoms. It can be treated by medicines such as glutamine tablets and methylcobalamin tablets. 3. Lumbar spine disease: right leg numbness and swelling may also be caused by lumbar spine disease, such as lumbar spine hyperplasia, lumbar disc herniation, lumbar muscle strain injury, etc., lumbar vertebrae nerve root compression and stimulation, thus causing right leg numbness and swelling, can be treated through surgical procedures, such as intervertebral disc removal surgery to relieve. If numbness and swelling of the right leg occurs, you should consult a doctor in time, take the appropriate treatment plan, and use medication strictly under the guidance of the doctor.