Currently, depending on the graft it can be classified as bone marrow source, or hematopoietic stem cell source, or it can be derived from umbilical cord blood, so bone marrow transplantation and hematopoietic stem cell transplantation are two different kinds of grafts. Bone marrow transplantation is often done directly from the donor, while hematopoietic stem cell transplantation is often done by using a cell separator to collect the hematopoietic stem cells from the donor after processing the donor. Each has its own advantages and disadvantages in the treatment process, because the process of collecting bone marrow includes mesenchymal stem cells in addition to hematopoietic stem cells, which are more likely to be viable in the patient’s body and may have a faster hematopoietic recovery time. Hematopoietic stem cell transplantation mainly involves the collection of hematopoietic stem cells from the donor’s body through a machine that does not contain MSCs or their blood cell components, so the rejection after entering the patient’s body, including the recovery time, may be slightly slower than bone marrow transplantation, but both can treat malignant blood diseases and are the main grafts for transplantation. . Some units use bone marrow + peripheral blood stem cells together for semi-compatible transplantation back to the patient.