The causes of erythema on hands and feet are considered to be allergic skin diseases, syphilis and so on, as follows: I. Allergic skin diseases: Allergic skin diseases are mainly due to the erythema and pimples on the skin of hands and feet after contacting chemical and irritating substances, accompanied by itching, and even peeling and vesiculation will occur. In the treatment, you can orally take compound glycyrrhizin tablets and olopatadine hydrochloride tablets, and you can mix Dinaid cream and urea Vitamin E cream for external use. Second, syphilis: syphilis is mainly due to syphilis spirochete caused by a sexually transmitted diseases, mainly through sexual contact transmission, in the clinic can be seen on the hands and feet appear light brown erythema, and rarely accompanied by peeling and itching phenomenon. In treatment, benzylpenicillin can be injected intramuscularly or minocycline hydrochloride tablets can be taken orally. Therefore, for erythema on the hands and feet, it is necessary to go to a regular hospital, under the guidance of a dermatologist, to conduct the appropriate laboratory tests to guide the clinical treatment.