Large platelet ratio is generally harmless if it is caused by physiological reasons, but will be harmful if it is caused by pathological reasons (e.g. primary thrombocythemia, aplastic anemia).
1. Physiological low: mostly seen after bleeding, the self-coagulation mechanism is activated, causing large platelets to transform to small platelets and coagulate to stop hemorrhage, thus causing low ratio of large platelets. This is a normal physiological reaction and is not harmful.
2. Pathologically low: for example, primary thrombocythemia can cause dizziness and fatigue in mild cases, nosebleed, gastrointestinal bleeding, thrombosis, splenomegaly in severe cases, or even brain hemorrhage; for example, aplastic anemia can cause anemia, infection, bleeding, and in severe cases, life-threatening due to severe infection and bleeding.
It is recommended to go to the hospital, improve the examination, clarify the cause of the disease, and then give targeted treatment under the guidance of physicians.