Lung nodules that become lighter in density after anti-infective treatment are usually a sign of improvement. Lung nodules are imaging manifestations that can be caused by a variety of etiologies, such as inflammation, benign tumors, and malignant tumors. If the lung nodules become lighter after anti-infective treatment such as using antibiotics like amoxicillin and cefixime, it generally suggests that the lung nodules are caused by infectious diseases and the anti-infective treatment is effective, suggesting that the disease is getting better. If the density of lung nodules remains unchanged after a period of anti-infective treatment, it is important to consider that the nodules may be caused by other diseases, such as inflammatory pseudotumor, malignant tumors, or malignant tumors such as lung cancer. If lung nodules are found, it is recommended to consult a doctor in time to clarify the cause of the disease under the guidance of the doctor and follow the doctor’s instructions for treatment.