Brain injury is a very serious condition and patients often present with unconsciousness, also known as a coma. Depending on the severity of the patient’s condition, the degree of coma varies. Some patients only have mild impairment of consciousness, such as slight drowsiness or blurring of consciousness, call and response, and limb movement, the awakening time of these patients is relatively short, and the impairment of consciousness may be gradually recovered in about 24 hours or 3-7 days. Heavy craniocerebral injury patients in coma for a longer time, most patients need more than 1 month or even longer, depending on the severity of the disease, once encountered more than 3-5 years after the awakening of the patient in the clinic, but this is a very rare situation. Clinically, patients who have not awakened after more than 3 months are considered to be in a state similar to a vegetative state. Therefore, if a patient with severe craniocerebral injury has not awakened after more than 3 months, the chance of awakening is relatively small. In addition, patients with craniocerebral injury should undergo active treatment in the early stage, including medication, surgery, rehabilitation, sound stimulation, neurostimulation, hyperbaric oxygen therapy and so on, which are very useful means to help patients wake up in the early stage. As long as the craniocerebral injury is not extraordinarily severe, most patients are able to awaken.