Itchy toe crevices are considered to be caused by tinea pedis, foot eczema and contact dermatitis, which can be treated with topical antifungal ointment, oral antihistamine and topical glucocorticoid ointment as prescribed by the doctor. 1. Tinea pedis: most patients will have itchy toe crevices, large amounts of superficial skin loss and cracking and other symptoms. Patients can follow the doctor’s instructions to use antifungal topical cream treatment, such as terbinafine cream, bifonazole cream and so on. 2. Foot eczema: it may be caused by various reasons such as local humidity and climate, and mainly has the manifestation of erosion and itching of toe crevices. It can be treated with oral antihistamine drugs, such as loratadine, levocetirizine hydrochloride, etc. under the advice of the doctor. 3. Contact dermatitis: an allergic reaction due to contact with certain allergenic substances, such as shoes and socks, which can be manifested as toe crevice rash with itching. At this time you need to avoid re-exposure to sensitizers, and follow the doctor’s instructions to give topical glucocorticoid cream treatment, such as mometasone furoate, fluticasone propionate and so on. Patients with itchy toes, it is recommended that patients go to the hospital to identify the cause of treatment. Taking medication should be used in accordance with medical advice, not self-medication.