Cirrhosis and renal failure occur simultaneously, usually secondary to cirrhosis causing renal failure, with the primary pathogenesis treatment as the mainstay, and may be accompanied by symptomatic treatment of the kidneys. 1. The cause of cirrhosis should be clarified first. If it is caused by viral hepatitis, it should be treated with antiviral drugs (such as entecavir, lamivudine, adefovir); alcoholic hepatitis should be actively abstained from alcohol; autoimmune should be treated with glucocorticosteroids and so on. 2. To take drugs to protect the liver, such as compound glycyrrhizin, reduced glutathione and so on. 3. When renal failure is more serious, the patient’s body has more metabolite accumulation, electrolyte and acid-base balance disorder, dialysis treatment should be carried out in time. 4. When cirrhosis enters into the decompensated stage and renal failure is difficult to be corrected, combined liver and kidney transplantation can be performed. It should be noted that when the patients have cirrhosis secondary to renal failure, they should go to the hospital in time for examination and treatment under the doctor’s guidance.