A small proportion of grand mal seizures can be cured, and most patients can significantly improve their symptoms with medication. Some patients may have poor treatment results, depending on whether the cause of the grand mal seizure can be completely resolved, drug sensitivity and other factors. Grand mal seizures are characterized by loss of consciousness, bilateral symmetrical tonic followed by clonic movements, and can be caused by ischemia and hypoxia, cortical dysplasia, and other factors. If the primary disease is actively treated, after regular use of antiepileptic drugs, a small portion can be cured, and most of the grand mal seizures can be well controlled. In some patients, when the effect is not obvious through drug treatment or the drug cannot be tolerated, surgical treatment needs to be considered, such as anterior temporal lobectomy, cortical resection of the brain other than the temporal lobe, and epileptic foci resection. Patients with grand mal seizures should undergo formal treatment in a timely manner to avoid delays that may lead to aggravation of the condition.