Whether it’s arthritis or spondylitis, I always hear patients say, “I have inflammation and the doctor told me to take anti-inflammatory drugs, but I can’t get better. It is evident that some primary care physicians have confused two very different concepts of “inflammation”. The majority of us usually call “inflammation”, mostly refers to a reaction caused by bacterial infection, medically known as “infection”. For example, “pneumonia,” “bronchitis,” “cystitis” and so on, because of the erosion of bacterial microorganisms, resulting in local redness, swelling, heat and pain, elevated white blood cells (commonly known as high blood count), fever and other symptoms. The treatment should be based on the selective application of antibiotics, or “anti-inflammatory drugs” as they are often called, to treat the symptoms. The inflammation of arthritis is a kind of aseptic “inflammation”, which is not caused by bacterial microbial infections, but by various causes of lesions in the tissue itself. Since there is no bacterial infection, there is no question of using antibiotics, and doctors most often use a “non-steroidal anti-inflammatory and analgesic” drug. The term “anti-inflammatory” here refers to the elimination of the local inflammatory response of the tissue itself. The distinction between these two distinct concepts may seem absurd, but in real life, there is indeed a great deal of confusion. Therefore, to prevent the abuse of antibiotics, we need to understand the difference between the two types of inflammation, and secondly, it is recommended that the term “antibiotics” be used instead of “anti-inflammatory drugs” in both professional and popular medical terminology, and to make it more popular.