Myeloma, also known as multiple myeloma, may manifest urinary incontinence, with different stages of development of the disease and different degrees of influence. Multiple myeloma is a malignant tumor of the blood system, with the gradual aggravation of the disease, it will cause neurological damage, for example, the tumor compression of the nerves of the urinary system will cause urinary nerve dysfunction or loss of urinary nerve function, which will show weakening of the ability to control the urine, and the symptoms of frequent urination, urinary urgency or urinary incontinence. Multiple myeloma can also cause recurrent infections in the urinary system and respiratory system, and patients may suffer from vomiting, diarrhea, headache, polyuria, constipation and other symptoms. Treatment includes medications such as bortezomib and lenalidomide, and also bone marrow transplantation such as autologous hematopoietic stem cell transplantation, which can help to alleviate the disease and prolong survival.