Aminoglycoside antibiotics are powerful antibacterial activities against aerobic gram-negative bacilli, including Escherichia coli, Klebsiella, Pseudomonas aeruginosa, and Shigella. It is suitable for systemic infections caused by sensitive aerobic gram-negative bacteria, especially for Pseudomonas aeruginosa, Klebsiella, Escherichia coli with better effect. So infections caused by Gram-negative bacteria, such as meningitis, urinary tract infections, skin soft tissue infections, gastrointestinal tract infections, burn infections, bone and joint infections, etc. It is very effective with aminoglycoside antibiotics. In case of serious infections, aminoglycoside antibiotics alone are slightly less effective and combined with other antibiotics.