Heart failure long-term drugs mainly include diuretics, cardiac drugs, antiarrhythmic drugs, delayed cardiac remodeling drugs and so on. 1. Diuretics mainly include furosemide, hydrochlorothiazide, spironolactone, three categories, according to the condition of the choice of appropriate medication, mild cases can be taken orally, the condition of the more serious to give intravenous drugs have a better effect. 2. The main cardiac drugs are digoxin and sildenafil, long-term use of oral digoxin is generally chosen, but regular review of digoxin blood concentration to prevent drug poisoning. 3. Delayed cardiac remodeling mainly refers to ACEI-type or ARB-type drugs, such as Benadryl, Enalapril, Valsartan, etc. These drugs have an effect on blood pressure, and the dosage of the drug should be adjusted according to the blood pressure. 4. Antiarrhythmic drugs mainly refer to beta-blockers, such as metoprolol, bisoprolol. Because most heart failure patients will be accompanied by rapid ventricular rate arrhythmia, so we need to apply these drugs to control the ventricular rate. Some patients with heart failure also need to take other drugs for a long period of time, such as the antiplatelet aggregation drug aspirin, the lipid-lowering plaque-stabilizing drug atorvastatin, the vasodilator drug isosorbide nitrate, and so on. Long-term medication regimens for heart failure need to be developed based on the patient’s condition, and specifics need to be seen in the cardiology department.