If the lymphadenitis is caused by a bacterial infection, anti-infective medication may be given and the use of amoxicillin is useful. In some patients, lymphadenitis is caused by a fungal infection and amoxicillin is given, which may not be effective. It is also important to treat the patient’s condition with other medications or surgery. The causative organisms that cause lymph node inflammation are Staphylococcus aureus and hemolytic streptococcus, which are usually secondary to infections in other parts of the body. Clinical symptoms include enlarged lymph nodes, localized redness, swelling, heat and pain, and elevated body temperature. It is recommended to give appropriate antibiotics according to the type of infection and under the guidance of the doctor. Commonly used clinical antibiotics include penicillin, cephalosporin and so on. Amoxicillin belongs to the penicillin group of drugs, which can target a specific bacterial infection. Therefore, taking amoxicillin is effective for lymphadenitis caused by bacterial infection. If it is caused by a fungal infection, drugs such as fluconazole and itraconazole can be given. If the temperature exceeds 38.5°C, antipyretic and analgesic drugs such as ibuprofen and acetaminophen can also be given to relieve pain and reduce fever. If an abscess has formed, it can be treated by surgical drainage if necessary, which can eliminate the symptoms of swollen lymph nodes. To summarize, lymphadenitis can be treated with amoxicillin, but it needs to be done under a doctor’s supervision.