Submucosal elevation of gastric fundus is related to gastric smooth muscle tumor, gastric polyp and other diseases, and should also be alerted to gastric cancer. The lower part of gastric mucosa belongs to the part of gastric smooth muscle, once suffering from gastric smooth muscle tumor, it may lead to the phenomenon of bulging of gastric mucosa. Gastric smooth muscle tumor will not only affect the function of stomach, but also lead to excessive secretion of gastric acid, so most of the patients will have indigestion, acid reflux, belching and other symptoms. The gastric mucous membrane will induce polyps under long-term severe stimulation. Gastric polyps will cause the patient’s stomach wall submucosa bulge, gastric polyps will not be accompanied by symptoms in the early stage, polyps are too large will cause excessive secretion of gastric acid, which will affect the digestive function of the stomach, and some of the gastric polyps will also cause pyloric obstruction and lead to gastric emptying function is impaired. The submucosal elevation of the gastric fundus should also be alerted to gastric cancer, so it is better to extract biopsy tissue for pathological examination during gastroscopy to confirm the diagnosis.