Chemotherapy may produce a hair loss reaction, but not losing hair does not necessarily mean it is bad. As long as the treatment is effective and the tumor is able to shrink or is under control without growing, it means that it is working. Whether or not hair loss occurs is mainly based on the drug, and the patient’s response. Some drugs have more severe hair loss reactions, such as paclitaxel and docetaxel, which may produce more severe hair loss reactions, and there is no way to avoid hair loss completely. But there are drugs that don’t have significant hair loss reactions, such as pemetrexed, and fluorouracil may not have significant hair loss reactions. However, they may cause other reactions such as allergy, nausea and vomiting, so there are still more side effects from chemotherapy. In addition to hair loss, other side effects need to be taken seriously. In addition, hair loss can be reversible, and hair will grow back after chemotherapy is completed and nutritional status improves.