Localized skin tightening, most commonly in scleroderma. Scleroderma is also known as systemic sclerosis. As the name implies, it is a disease in which the skin becomes hardened. Changes in the skin are the hallmark symptom of systemic sclerosis. However, the extent of the lesions varies widely, from localized sclerosis and calcification of the skin in mild cases to widespread generalized sclerotic thickening of the skin in severe cases. The typical skin lesions go through three stages in sequence: swelling phase, infiltration phase and atrophy phase. The lesions are symmetrical, with gradual proximal expansion of the lesions from the fingers, and the boundaries between the lesioned skin and normal skin are indistinct. Local skin tightening is characterized by excessive collagen production and a significant increase in collagen content in the skin. Certain cytokines are involved in the pathogenesis of the disease, such as transforming growth factor, epidermal growth factor, and platelet-derived growth factor. Most patients with scleroderma exhibit Raynaud’s phenomenon, and pathology shows thickened intima, narrowed or occluded lumen of small arteries and microvessels. Local skin tightening examination: 1, scleroderma changes proximal to the metacarpophalangeal joint, which may involve the whole limb, face, whole body and drive stem. 2, Scleroderma of the fingers: the above skin changes are limited to the fingers. There is depressed scarring and loss of finger pads at the tips of the fingers. Basal fibrosis of both lungs. Other manifestations that contribute to the diagnosis: Raynaud’s phenomenon, polyarthritis or arthralgia, abnormal esophageal motility, dermatopathological collagen fibrous swelling and fibrosis, positive immunological tests ANA, anti-Scl-70 antibody, and attachment site antibody (ACA).