The difference between genital herpes and eczema includes different causes, different clinical manifestations, and different treatment methods. 1. Etiology:Genital herpes is caused by herpes simplex virus infection of the anogenital skin and mucous membranes; eczema etiology is not clear, and is related to a variety of internal and external factors. 2. Clinical manifestations: genital herpes is mainly manifested as erythema, clustered blisters, vesicles around the genitals or anus, which can be accompanied by inguinal lymph node swelling and pain, fever, headache, malaise and other systemic symptoms; eczema can occur in the genital area, manifested as skin erythema, pimples, vesicles, scabs, etc., often accompanied by itching. 3. Treatment: genital herpes is mainly based on antiviral treatment, the use of antiviral drugs, such as vasiclovir, ganciclovir, etc.; eczema treatment, oral antihistamine treatment, such as loratadine, cetirizine, etc., and topical glucocorticosteroid treatment, such as hydrocortisone cream. All of the above medications should be used under a doctor’s supervision. Genital herpes and eczema are two different diseases, it is recommended that patients who can not clearly distinguish between them need to go to a regular hospital in a timely manner, a clear diagnosis, and follow the doctor’s instructions for reasonable treatment. Do not blindly self-medication.