Lung nodules that have not changed after ten days of anti-infective treatment may be the result of an incorrect anti-infective regimen that needs to be adjusted, or the cause of the lung nodules is not due to an infectious disease, so the anti-infective regimen is ineffective. The nature of lung nodules can be benign or malignant. Benign nodules include benign tumors, infections, inflammatory lesions, and pulmonary vascular abnormalities, while malignant lesions include primary lung cancer and metastatic lung tumors. Lung nodules caused by infectious factors may become smaller or even disappear after anti-infective treatment. Intravenous infusion of anti-inflammatory drugs, nodules do not significantly shrink, need to further determine whether the current anti-infective regimen used is sensitive to pathogens. If the infection is caused by fungi, Mycobacterium tuberculosis and other pathogens, anti-fungal and anti-tuberculosis medications should be used, and antibiotic treatment is ineffective. Secondly, if the lung nodules are caused by infectious factors but are now old, anti-infective treatment is also ineffective. In addition, if the lung nodules are caused by non-infectious factors such as tumors and lung vascular anomalies, and the size of the lung nodules does not change after anti-infectious treatment, the treatment plan should be adjusted under the guidance of the doctor in a timely manner. If you find lung nodules, it is recommended that you consult a doctor in a timely manner, under the guidance of the doctor, improve the examination, clarify the cause of the disease, and follow the doctor’s instructions for treatment.