Vitamin E capsules, also known as vitamin E softgels, should not be applied directly to the face; the drug is an oral medication, and topical application may lead to symptoms of skin irritation or even contact dermatitis. The main ingredient of vitamin E softgels is vitamin E. It also contains gelatin, glycerin and other excipients. The drug can be taken orally to treat cardiovascular and cerebrovascular diseases, habitual abortion, and can also assist in the treatment of infertility. After taking the drug, adverse reactions such as nausea, vomiting, dizziness and headache may occur. It is contraindicated for those who are allergic to the components of the drug. The drug is taken orally, and no studies have confirmed that the drug can be used externally. Applying the contents of the capsule to the face may lead to symptoms of local irritation, such as itching and burning, and may even cause symptoms of contact dermatitis, such as erythema, papules and pimples, to appear at the site of application. At the same time, the drug instructions clearly state that oral treatment is required, but not written to be used externally. Patients are advised to use Vitamin E Soft Capsules under the guidance of a specialist and not to change the route of administration or the dosage of the drug on their own to avoid adverse reactions.