Taking medications orally with meals means taking medications at the same time as meals, which is mainly seen in taking hypoglycemic drugs, antifungals, certain antibiotics, and certain anti-hypertensive drugs. Part of the drug with meals can enhance the efficacy of the drug to give full play to the role of drugs, but also some drugs need to be taken with meals in order to reduce the adverse effects of drugs, reduce the stimulation of the gastrointestinal tract. 1. hypoglycemic drugs: acarbose and voglibose need to be taken at the first bite of the meal, glimepiride needs to be taken before or during breakfast, and must be eaten immediately after taking. Metformin can cause gastrointestinal discomfort, so it should be taken with a meal. 2. Antifungal drug ashwagandha: This drug, if consumed together with high-fat food, can promote drug absorption, increase efficacy and reduce gastrointestinal side effects. 3. Certain anti-hypertensive drugs: Carvedilol, for example, can slow down the absorption of the drug when taken with a meal. 4. Certain antibiotics: Clarithromycin tablets can reduce gastrointestinal adverse reactions when taken with meals. The use of specific drugs need to be under the guidance of a professional doctor, do not judge the use of drugs to avoid danger. The above medications are in accordance with the doctor’s instructions.