Herpes has various etiologies, mostly chickenpox or herpes zoster caused by infection with varicella-zoster virus, which is a respiratory virus, most often presents after 1 day of fever as a red maculopapular rash that quickly evolves into a herpes and crusts, and can be seen in a patient with four generations of maculopapular, papular, herpetic and crusted rashes, with significant itching and scarring. In HFMD caused by enterovirus infection, the main routes of infection are the respiratory and digestive tracts. Red papules can progress to herpes, varying in size and number, without pain or itching and leaving scars. Herpes caused by allergies can be seen as large herpes and epidermal peeling, which can be serious and life-threatening.