Hypertensive nephropathy creatinine between 140~150μmol/L belongs to relatively serious, but if it is actively treated, there is hope to maintain stable renal function in the long term. The early stage of hypertensive nephropathy is mainly manifested as renal interstitial-tubular injury, creatinine between 140 μmol/L and 150 μmmol/L, which indicates that about half of the renal function is lost; hypertension damages the kidneys, and at this time, there are often also other target organ damages, such as the heart, cerebral blood vessels and so on. Therefore, in general, the condition is relatively serious. For the treatment of hypertensive renal damage, it is necessary to actively control blood pressure, oral valsartan, nifedipine extended-release tablets, etc., as prescribed by the doctor, to strictly control blood pressure and delay the progress of the disease; at the same time, it is necessary to pay attention to the maintenance of the stability of other related complications, such as the combination of anemia, can be orally administered iron polysaccharide, combined with acidosis, oral sodium bicarbonate and so on; can also be prescribed oral detoxification drugs, such as renal failure and so on. Patients with hypertensive nephropathy with elevated creatinine are advised to go to regular hospitals in time and receive standardized treatment under the guidance of physicians.