Diffuse hepatic changes must first be determined by the nature of the lesion, if malignant lesions are not considered, the liver is in the compensatory phase, and life expectancy is generally unaffected. If the patient is considered to have diffuse hepatitis B changes, if the patient is considered to have cirrhosis and the patient has ascites, and if the patient is in the decompensated phase of the liver with significant abnormalities in liver function, the patient’s life expectancy is significantly shortened, and the patient will soon have liver failure and gastrointestinal bleeding, which can jeopardize the patient’s life. If diffuse lesions are considered fatty liver or alcoholic cirrhosis, the changes will be reduced by lowering blood lipids and abstaining from alcohol. If the patient is then intervened with medication, the patient’s life expectancy will not be affected much in the short term, but it is important to have regular reviews, and in general the patient’s life expectancy will not be affected much overall. If diffuse changes are considered to be caused by a malignant tumor of the liver and the patient has significant cirrhosis, the tumor is inoperable or can only be palliatively operated on, and the general life expectancy is 1-2 years.