Repeated epigastric pain in celiac gastritis can be given medication to relieve symptoms, and if Helicobacter pylori infection exists, eradication treatment should be carried out, and daily attention should be paid to avoiding its triggering factors to prevent recurring epigastric pain. Celiac gastritis is divided into acute celiac gastritis and chronic celiac gastritis. The recurrence of epigastric pain in patients with celiac gastritis is related to drug stimulation, alcohol consumption, Helicobacter pylori infection, and stress factors that cannot be relieved. Recurrent epigastric pain in celiac gastritis requires timely clarification of the causes and triggers that lead to its recurrence and targeted treatment. Such as should strictly abstain from alcohol, avoid taking aspirin and other non-steroidal anti-inflammatory drugs, maintain emotional stability. The presence of Helicobacter pylori infection should be treated with a four-pronged approach, i.e., a proton pump inhibitor such as omeprazole + a bismuth agent such as colloidal bismuth + two antibiotics such as amoxicillin and clarithromycin for eradication. When epigastric pain occurs, it should pay attention to a light liquid diet, more rest, and give gastric mucosal protectants such as magnesium aluminum carbonate, aluminum thioglycollate and drugs to inhibit gastric acid secretion such as omeprazole and lansoprazole to relieve the pain. Patients with repeated epigastric pain in erosive gastritis should consult a doctor in time and follow the doctor’s instructions for standardized treatment to avoid delaying the condition, leading to gastric hemorrhage and other serious conditions. The specific use of drugs need to follow the doctor’s instructions.