There are more than 1200 autosomal recessive disorders, and the most common clinical ones are the following: phenylketonuria, cystic fibrosis of the pancreas, congenital glucuronosyltransferase deficiency, lianocytic anemia, Fanconi syndrome, albinism, galactosemia, hepatomegaly, congenital lactase deficiency, glucose-galactose malabsorption, hereditary fructose intolerance, glycogen accumulation disease type, maple diabetes mellitus, methylmalonic acidemia, propionic acidemia, valproic acidemia, congenital hyperammonemia, etc. In autosomal recessive inheritance, if both parents are heterozygous, the next generation will have a 1/4 chance of having a diseased offspring. Therefore, detection of carriers for some inborn metabolic defects is also an effective preventive measure to prevent the birth of children with the disease and improve the quality of life of the children born.