The small grains of rice on the corners of the mouth may be caused by acne, milia, and perioral dermatitis, which can be removed through general treatment and medication. 1. Acne: A lot of small grains of rice on the corners of the mouth may be caused by acne, it is recommended that patients eat less spicy and stimulating food, you can follow the doctor’s instructions for the topical use of Vitamin A acid, adapalene and other Vitamin A acid drugs, with anti-inflammatory, dissolve acne and other effects. In addition, you can also use topical benzoyl peroxide and other drugs, which can kill Propionibacterium acnes and promote recovery. 2. Corns: The corners of the mouth with a lot of small grains of rice are considered to be related to corns, the patient should keep the local clean, it is recommended to use topical retinoic acid drugs under the guidance of the doctor, such as adapalene, tazarotene and other gels, to help dissolve pimples, promote the renewal of the epidermal cells, or if necessary, for the treatment of the needle clearing. 3. Perioral dermatitis: the corners of the mouth with a lot of small grains of rice may be due to perioral dermatitis, the patient should pay attention to personal hygiene, you can comply with the doctor’s instructions for the external use of antibiotics, such as erythromycin, clindamycin, etc., with the role of sterilization, help the disease recovery. There are many reasons why the corners of the mouth have a lot of small rice grains, it is recommended that patients seek medical examination to identify the causes, and cooperate with the doctor for standardized treatment.