Itchy and painful urethral opening in women is considered to be caused by a urinary tract infection, which can be treated with oral antibiotics and attention to drinking more water and refraining from holding urine. It may also be caused by allergy, you can give oral anti-allergy drugs, such as paracetamol, or apply cortisol hormone ointment locally to solve the itchy and painful urethra. You can also wash the affected area with cleansing lotion or gynecological lotion to keep the area clean, and do not wear chemical fiber underwear. If the itchy and painful urethral opening occurs in older women, it may be related to estrogen deficiency, and local application of estrogen ointment can be given, which may relieve the itchy and painful urethral opening in women.