Urine protein 4+ suggests the presence of a large amount of proteinuria. It is usually seen in nephrotic syndrome caused by various reasons. It is recommended to go to the hospital for further examination to clarify the cause of the disease and treat the cause. Various causes of nephrotic syndrome (e.g. microscopic lesions, membranous nephropathy, FSGS, diabetic nephropathy, etc.) can lead to urine protein 4+. Kidney damage caused by some medications (e.g. antibiotic drugs, etc.) can also make the test result of urine protein 4+ occur in the urine test. Physiologic increase in urine protein can occur when the environment is high heat and cold. Increased urine protein also occurs when there is overwork and mental stress. At this time, there is no need for special treatment, you can change the environment in which you live, and keep your mood happy on a daily basis. However, this cause of proteinuria, usually the amount of urine protein will not be too much. However, urine protein 4 + pathologic factors due to the possibility of large, it is recommended that the patient in time to the regular hospital, under the guidance of the physician to improve the relevant examination, follow the doctor’s instructions for treatment.