Whether celiac gastritis with enterocolitis is serious depends on the patient’s own disease. Drugs such as acid-suppressing and gastric mucosa-protecting agents and antibiotics need to be applied. Erosive gastritis refers to the erosion of gastric mucosa caused by various reasons, while enterosis refers to intestinal epithelial hyperplasia, which is the replacement of gastric mucosal cells by intestinal epithelial cells, manifested as gastric mucosal atrophy, which is due to the stimulation of chronic inflammation in the stomach and other reasons, and is prone to malignant changes if left untreated for a long time. If the patient is in mild celiac disease with intestinalization, drug treatment is usually taken, applying gastric acid inhibitors, such as omeprazole, lansoprazole, etc., gastric mucosal protectants, such as magnesium aluminum carbonate, bismuth potassium citrate, etc. If combined with Helicobacter pylori infection, antibiotics, such as amoxicillin, clarithromycin, are also needed to carry out Helicobacter pylori eradication treatment. If the patient’s celiac disease with enterocolitis is more severe, in addition to drug treatment, it may be necessary to evaluate whether surgical treatment is needed, such as surgical resection of diseased tissue. Patients should seek timely medical attention, and the use of medication should be under the guidance of a doctor, and should not be used blindly to avoid delaying the condition.