High fever in leukemia patients is usually due to tumor fever caused by the leukemia itself, and requires aggressive chemotherapy to reduce the load from the tumor. It may also be poor resistance and infection, which can be treated with antibiotic drugs. 1. Tumor fever caused by leukemia: tumor fever is caused by thermogenic factors secreted by tumor cells, firstly, active chemotherapy is needed to carry out anti-tumor treatment, and the drugs include cytarabine, zorubicin and so on. Secondly, ibuprofen and glucocorticoid drugs (dexamethasone) can be used to control the body temperature temporarily, with caution for patients with allergy and severe mental illness. 2. High fever caused by infection: leukemia patients with high fever combined with infection can be treated with antibiotics, commonly used antibiotic drugs are imipenem, meropenem, etc. The above drugs should be used under doctor’s supervision. The above drugs need to be used under the guidance of a doctor to avoid adverse reactions and aggravation of the condition.