Primary lung cancer will become the leading cause of death among Chinese residents. At present, surgical resection is still the main means of cure, but because of the low early detection rate of primary lung cancer, about 85% of which are non-small cell lung cancer, 40% of these patients are already locally advanced or have metastasis at the time of diagnosis; moreover, most patients are of advanced age and not many of them can undergo surgical resection; although chemotherapy and radiotherapy have been greatly developed in recent years, they still have their limitations and are far from being curative. In recent years, new minimally invasive treatment techniques have become a hot spot in malignant tumor treatment, and have been greatly developed in the treatment of primary lung cancer. Radiofrequency treatment of solid tumors with cluster electrodes is a rapidly developing minimally invasive technique in recent years, which has been widely used in the treatment of primary liver cancer and metastatic liver cancer, and has achieved good efficacy. In recent years, it has also been applied to the treatment of lung cancer. In November 1999, our hospital started to apply this new technology to the treatment of unresectable non-small cell lung cancer, and found that percutaneous lung puncture radiofrequency treatment with cluster electrodes could indeed destroy lung cancer tissues and completely inactivate local tumors or reduce tumor load. With the rational application of comprehensive treatment and the emergence of new drugs and protocols, the treatment level of NSCLC has improved to some extent, but still has its limitations and is far from being curative. At present, the standard treatment for locally advanced NSCLC that cannot be surgically removed due to technical or medical reasons (e.g. cardiopulmonary insufficiency) or patient’s refusal of surgery is radiation therapy or plus chemotherapy. However, the current local recurrence rate of ordinary radiation therapy for non-small cell lung cancer is as high as 80% [22, 23], and local recurrence and systemic metastasis are the main causes of death in locally advanced non-small cell lung cancer. With the establishment of bio-psycho-social medicine model, improving the quality of patient survival has become an increasingly important topic in the treatment of malignant tumors. In recent years, new minimally invasive treatment techniques have become a hot spot in malignant tumor treatment, and have been greatly developed in the treatment of primary lung cancer. 1. Lung cancer and survival quality From the perspective of modern medicine, it is important to reflect not only biological indicators but also psychological health assessment and assessment of social activity function to determine the degree of health and efficacy. Many studies [24, 25] have shown that people have recognized the importance of survival quality assessment; from now on, lung cancer is still a disease that cannot be cured fundamentally, and survival quality has been identified as an important prognostic factor and as the ultimate goal for effective disease treatment, while the former also provides an important objective basis for patients to formulate and select treatment plans. Especially for patients with lung cancer combined with distant metastases, it is believed that improvement of survival quality should be identified as the goal, or even the only goal, of cancer treatment for patients whose disease has entered the middle and advanced stages. In the treatment of advanced non-small cell lung cancer, chemotherapy or radiotherapy and chemotherapy combined with radiotherapy have been shown to improve survival, but the quality of survival is often affected by the occurrence of severe adverse effects; especially for those with poor body condition, a few of them can cause serious consequences such as death, so these patients sometimes have to be treated with supportive therapy only; in this case, how to find a treatment that can both reduce tumor load and improve survival? In this case, it is important to find a treatment method that can reduce the tumor load and improve the quality of patients’ survival. Radiofrequency (RF) can be radiated via antennas in the frequency range from 3 KHz to 3 OOOGHz and is called radiofrequency [26]. Usually the current frequency for RFA applications is between 350 KHz- 500KHz [27]. The high frequency conversion sinusoidal current generated by RF machine is introduced into the surrounding tissues by electrodes, and the ions in the tissues frequently oscillate with the conversion of positive and negative current, while the polar biomolecules frequently change their polarization direction with the conversion of current direction, which generates frictional effects in both ways, converting electrical energy into heat and increasing the temperature of the tissues [28]. The self-stabilizing mechanism of tissue cells allows them to maintain normal function in an environment of about 40°C. When the ambient temperature rises to 4245″C (i.e.