The main cause of intrahepatic stone colic is the irritation of the bile duct wall by the stone, which leads to inflammatory narrowing of the bile duct and a series of complications caused by the stone. 1. Intrahepatic bile duct stones can directly stimulate the wall of the bile duct, leading to spasm and inflammatory stenosis of the bile duct, resulting in increased pressure in the bile duct, and the patient may experience epigastric pain. 2. Inflammatory stenosis of the bile duct can cause poor bile drainage and aggravate biliary tract infection, which will further aggravate the inflammatory stenosis, resulting in persistent epigastric pain. 3. Long-term and repeated stimulation of intrahepatic bile duct stones can trigger intrahepatic bile duct cancer, causing cancer pain in patients. When intrahepatic stone colic occurs, it is necessary to consult a doctor in time, and improve the relevant examination, under the guidance of the doctor for standardized treatment.