The treatments for duodenal ulcer include eradication of Helicobacter pylori, antacids, acid inhibitors, gastric mucosal protective drugs, endoscopic treatment, and surgical treatment. 1. Eradication of Helicobacter pylori (Hp): Hp eradication therapy alone can heal more than 90% of duodenal ulcers with two antibiotics (e.g., amoxicillin, clarithromycin), a bismuth agent (e.g., colloidal bismuth pectin) and a proton pump inhibitor (e.g., lansoprazole). 2. Antacids: can neutralize stomach acid and relieve pain, including sodium bicarbonate, calcium carbonate, magnesium hydroxide and aluminum hydroxide. 3. Acid inhibitors: (1) Hâ‚‚ receptor blocking drugs: such as cimetidine, ranitidine and so on. (2) Proton pump inhibitors: preferred drugs for duodenal ulcer, including omeprazole, lansoprazole, rabeprazole, etc. (4) Gastric mucosal protection drugs: can protect and enhance the defense function of gastric mucosa, including misoprostol, bismuth, aluminum thiosulfate, etc.. 5. Endoscopic treatment: (1) Spraying norepinephrine and thrombin under direct endoscopic vision. (2) Local injection of epinephrine, sclerosing drugs, adhesives, etc. (3) Use of electrosurgical equipment such as thermal probes, thermal biopsy forceps, and argon ion coagulation. (4) Use of titanium clamps for hemostasis, etc. 6. Surgical treatment: large amount or repeated bleeding, internal medicine treatment is invalid, acute perforation, chronic penetrating ulcers, stubborn and refractory ulcers, etc. Surgical treatment is feasible. The above drugs should be used under the guidance of professional physicians. Patients with duodenal ulcers should not use their own medication, and should go to the hospital in time, under the guidance of doctors to standardize treatment.