The following diseases should be considered: 1. Hypokalemia, also known as hypokalemic periodic paralysis, in which the patient’s blood potassium decreases, resulting in weakness of the extremities, more pronounced in both lower extremities, often mainly proximal, which can improve after symptomatic treatment with potassium supplementation. 2. Spinal cord lesions, more common with acute myelitis or spinal cord infarction, can also be spinal cord compression caused by disc herniation or traumatic injury. Compression disorder. Patients present with motor, sensory, and autonomic dysfunction below the plane of injury, with motor deficits manifested as bilateral leg weakness and inability to stand.3. Muscle disease, acute polymyositis can also lead to sudden onset of bilateral lower extremity weakness, but often both upper extremities are also involved, characterized by significantly elevated serum muscle enzyme profiles and abnormal inflammatory indexes.4. Cerebrovascular disease in special cases, if bilateral cerebral hemispheres occur simultaneously injury, there may also be bilateral lower limb weakness, but it will be accompanied by other clinical signs and symptoms, such as cranial nerve damage as well as upper limb weakness symptoms.