If you drink alcohol after taking azithromycin, it does not cause serious disulfiram-like reactions like beta-lactams, but if you drink alcohol after taking azithromycin, the following symptoms will occur: First, obvious digestive discomfort, aggravated nausea, vomiting, abdominal distension, acid reflux, heartburn, and in severe cases, colic around the umbilicus, accompanied by dilute watery stools. Second, if you take azithromycin and then drink alcohol, it will also aggravate the reaction after alcohol, such as aggravating drunkenness or rash, rash, pimples on the body, skin rash, allergic-like reaction, etc. Third, if you have taken azithromycin relatively more or have had alcoholism in the past, taking azithromycin and drinking alcohol will cause significant tachycardia, palpitations, chest tightness, shortness of breath, and even transient dyspnea.