Penile folliculitis with a large lump on pressure may be caused by bacterial infection, and the patient will have symptoms of boils or carbuncles. It is recommended that patients take medication and surgical treatment to deal with the problem. A large lump on pressure is a typical symptom of folliculitis. Folliculitis is caused by a bacterial infection, and the patient will have symptoms such as pimples or pustules, and if the patient’s condition further aggravates, boils or carbuncles may appear, and accompanied by itching, tenderness or spontaneous pain. It is recommended that patients with penile folliculitis take timely treatment, patients can use chlorhexidine gluconate solution, povidone-iodine solution or povidone-iodine solution and other antibacterial lotions for rinsing, can also use mupirocin ointment, fusidate cream and other antibiotic creams for treatment. If necessary, surgical treatment can be taken to incise the lesion and drain the pus. Patients with penile folliculitis should seek medical attention when a lump develops. Patients should be treated under the guidance of a doctor to avoid blind medication.