The HFMD vaccine is an inactivated vaccine, called Enterovirus 71 inactivated vaccine, which is mainly used to prevent HFMD caused by Enterovirus 71 infection. Because there are more than 20 types of enteroviruses that cause HFMD, most of which are mild, and the majority of patients with severe HFMD are caused by enterovirus 71 infection, vaccination against HFMD is clinically important to reduce the prevalence and mortality of severe HFMD. The vaccination for HFMD is 2 shots in total, usually at an interval of 1 month, and it is not possible to determine whether a follow-up booster immunization is needed. The site of reception is an intramuscular injection of the deltoid muscle of the upper arm, and the vaccination for HFMD should also be observed for allergic reactions to vaccination, etc.