The causes of osteoarthritis are clinically unknown and may be related to one’s own condition, genetics, at the time of trauma, and age. In the case of primary osteoarthritis, the cause is not entirely clear, and is generally believed to be due to a combination of systemic or local factors, such as stress imbalance, cerebellar imbalance, cumulative minor trauma, nutritional deficiencies, and endocrine disorders. If secondary osteoarthritis is present, it is generally a secondary change on the basis of the original fracture or arthritis, which is commonly caused by joint deformity, fracture, joint strain, infection and other factors. The pain symptoms of osteoarthritis are also related to weather changes, exertion and other factors. Non-steroidal anti-inflammatory drugs, such as celecoxib, are usually used to treat the pain. It is recommended to consult a doctor as soon as possible for a clear diagnosis and treatment. All of the above drugs should be used under the guidance of a physician, avoid self-medication.