1, women of childbearing age taking estrogen, progesterone oral contraceptives, also have a reducing effect on hypoglycemic drugs, need to switch to other contraceptives. 2, diabetic patients suffering from tuberculosis, if the combination of methylglycine and isoniazid, rifampin, the latter will accelerate the metabolism and excretion of methylglycine, worsening diabetes, which can lead to coma, so you need to switch to streptomycin, nitrogen thiourea, sodium p-aminosalicylate treatment of tuberculosis. 3, diabetic patients suffering from hypertension when injecting insulin, and taking lispro will hinder the release of norepinephrine, so that blood glucose lowered, thus enhancing the role of insulin, hypoglycemic reactions can occur, so change to hypotension, Xia Gu Cao, chrysanthemum and other treatment of hypertension. 4, diabetic patients use chloramphenicol due to intestinal infection, the drug can slow down the metabolism of oral hypoglycemic drugs, which can easily cause hypoglycemia. While taking chloramphenicol, need to switch to hypoglycemic or hypoglycemic tablets metformin to treat diabetes. 5, patients suffering from diabetes and bronchitis, if the combination of methotrexate and sulfa drug Synthroid, will increase the blood concentration of hypoglycemic drugs, hypoglycemia can occur, so the two drugs should be used at intervals. 6, diabetic patients suffering from thrombophlebitis, if methylglycine and double coumarin together, methylglycine can replace the latter, so that its concentration increases, causing bleeding; and double coumarin can inhibit the metabolism and excretion of methylglycine, prone to hypoglycemia. Therefore, it is not suitable for combined use. 7, diabetic patients suffering from rheumatic fever, if aspirin and euglycemia, methotrexate, chlorosulfaprepitant, etc., aspirin can replace oral hypoglycemic drugs, but also slow down the metabolism and excretion of hypoglycemic drugs, and then aspirin itself also has hypoglycemic effect, resulting in hypoglycemic coma, so it is appropriate to use naproxen to treat rheumatic disease. 8, in addition, tetracycline, oxytetracycline, gentamicin, kanamycin, etc. and hypoglycemic combination, can produce a lot of lactic acid, easy to cause acidosis, and even life-threatening, so need to switch to other antibacterial drug therapy.