(Disclaimer: This article is only used for scientific purposes, in order to protect the privacy of patients, the relevant information in the following content has been processed) Abstract: 44-year-old Ms. Zhang, who had a history of chronic hepatitis B, stable condition, due to taking medication to treat dermatological diseases, stopping the use of anti-hepatitis B virus medication on their own, 2 weeks after the emergence of chronic hepatitis acute, resulting in liver failure, diagnosed as chronic viral hepatitis B severe, belonging to the chronic Diagnosed as chronic viral hepatitis B severe, belonging to the more serious type of chronic hepatitis, the patient’s clinical symptoms were basically relieved, and the indicators gradually recovered after being actively given hepatoprotective treatment, and at the same time cooperating with the drugs for lowering the yellow color and lowering the enzymes. Basic information] Female, 44 years old [Disease type] Chronic hepatitis [Hospital] No.988 Hospital of PLA Joint Command and Security Forces [Date of consultation] October 2021 [Treatment plan] Drug treatment (compound glycyrrhizin injection, polyenophosphatidylcholine injection, reduced glutathione for injection, hepatic relief injection, hydrocortisone injection, tenofovir disoproxil fumarate tablets) [Treatment cycle] Hospitalization for 35 days. Treatment cycle] 35 days of hospitalization, 3 months of outpatient follow-up 【Treatment effect】 Clinical symptoms disappeared, liver function indexes and quantitative indexes of hepatitis B virus returned to normal I. Initial consultation A middle-aged female patient came to the office during the last day, the first impression of the skin mucous membrane is like a layer of golden film, the sclera is also a heavy yellowish color, the patient said: 1 week ago, found that the color of urine is yellow like strong tea, especially in the morning, and then she had no desire to eat, nausea after meals, stomach pain. Do not want to eat, nausea after meals, stomach bloating, hiccups symptoms, oral medication is not effective. 3 days ago, the family found that the skin and the whites of the eyes are also yellow, so decided to consult the doctor, asked about the history of the patient learned that the patient has a history of hepatitis B, has been orally entecavir tablets antiviral treatment, the condition has been relatively stable, 2 weeks ago due to the skin disease to take Chinese herbal medicines, and entecavir tablets stopped, who knows that now this situation. After listening to the patient’s account, he had a diagnosis in his mind, and then he was prescribed liver function and blood coagulation tests, and the results of the liver function showed that: total bilirubin: 263 μmol/L; direct bilirubin: 179.5 μmol/L; indirect bilirubin: 83.5 μmol/L; alanine aminotransferase: 140 U/L; glutamic oxalate aminotransferase: 87 U/L; blood coagulation showed that: thromboplastin time: 28.1S; thromboplastin time: 28.1S; thromboplastin time: 28.1S; thromboplastin time: 28.1S; thromboplastin time: 28.1S. 28.1S; prothrombin activity 25.1%, so the diagnosis was chronic viral hepatitis B severe, which belongs to the more serious type of chronic hepatitis, and the patient was admitted to the hospital for treatment. After admission, the patient actively cooperated with the treatment, but the patient’s liver function was severely damaged, total bilirubin was more than 171μmol/L, prothrombin activity was less than 40%, the diagnosis of severe hepatitis was clear, and the prothrombin activity was 25.1%, and according to the past clinical experience, the survival rate was only 25%, the patient was only 44 years old, but the disease was really very serious, and the patient’s family communicated with the family, and the family said that they would treat the patient at all costs. After communicating with his family, the family expressed that they would treat the patient at all costs, so we gave him compound glycyrrhizin injection, polyenophosphatidylcholine injection, reduced glutathione for injection, shu hepatic injection and other drugs intravenously, on the basis of hepatoprotective, yellow-lowering and enzyme-lowering treatments, and in addition, we gave the patient tenofovir disoproxil fumarate tablets for antiviral treatment, added fresh plasma for intravenous transfusion, and gave him hydrocortisone injection for intramuscular injection to prevent overly strong hormone therapy. Hormone therapy was also given to prevent the strong immune response and prolong the treatment time to save the patient’s condition. After the joint efforts of doctors and patients, the liver function of the patient finally stopped deteriorating on the 10th day of hospitalization, the total bilirubin and aminotransferase began to decline, and the prothrombinogen activity increased, the condition improved and the patient’s life was saved. After 35 days of treatment, the patient’s skin, mucous membrane and sclera yellow staining completely subsided, urine returned to normal, good spirit, appetite returned to pre-sickness level, nausea, abdominal distension disappeared, because of compound glycyrrhizic acid glycoside injection has the effect of treating dermatosis, the patient’s dermatosis also followed the improvement. Review of liver function: total bilirubin decreased to 37.8 μmol/L, ghrelin and ghrelin were normal, prothrombin activity increased to 90%, and the patient was discharged from the hospital. Precautions We are glad that the patient’s chronic hepatitis can be controlled, but we still need to advise the patient and his family to pay attention to the fact that after discharge from the hospital, we still need to continue the patient’s observation of urinary and fecal conditions, and to test the liver function and hepatitis B virus quantification every month, and then extend the period to review every 3 months after 3 consecutive months of normalization. In daily life, attention should be paid to strengthen nutrition and reasonable diet for patients. Pay attention to rest, avoid overwork or staying up late for a long time, take part in outdoor activities such as walking, jogging, playing badminton, etc. Maintaining a cheerful mood and optimistic mentality will help to enhance one’s physical fitness. The liver is the largest metabolic organ of the human body, chronic hepatitis patients should develop the habit of protecting the liver in daily life, and must consult the doctor in time when there is any abnormality in the body, so as to avoid delaying the condition. In addition, according to this patient should also be reminded of poor liver function or patients with chronic hepatitis: 1, see the doctor do not take medication, before taking medication to inform the doctor of past medical history and a detailed understanding of the adverse effects of the drugs used to prevent drug liver injury; 2, contraindication to discontinue the use of anti-Hepatitis B virus medication on their own, the fastest after the discontinuation of the fastest 2 weeks, as slow as half a year can be a large number of viral replication, the serious can be a liver failure and death; 3, Be sure to regularly review liver function, hepatitis B virus DNA quantification, liver, gallbladder, pancreas and spleen ultrasound, alpha-fetoprotein, in order to keep abreast of changes in the condition.