Metformin is a glucose-lowering drug, and uric acid-lowering drugs have different pharmacological effects, will not affect each other, can be taken together, but should be taken under the guidance of a doctor. Metformin is a biguanide glucose-lowering drug, used for the treatment of type 2 diabetes mellitus, especially for obese type 2 diabetes mellitus patients. Adverse reactions of Metformin include nausea, vomiting, diarrhea, abdominal pain, abdominal distension, and fatigue. Contraindications: allergic to the product, diabetic ketoacidosis, severe hepatic and renal insufficiency, heart failure, acute myocardial infarction, pregnancy and lactating women. Common uric acid-lowering drugs are: benzbromarone, allopurinol, febuxostat and so on. When taking uric acid-lowering drugs should be avoided to take drugs that cause uric acid to rise, such as thiazide diuretics, glucocorticosteroids, pyrazinamide and so on. Metformin and uric acid-lowering drugs need to be taken under the guidance of a doctor.