Whether intestinal ulcer is a very serious disease needs to be considered according to a variety of factors such as the progress of the patient’s condition, complications, etc. If the condition is controlled in a timely manner, it is generally not serious; if the disease develops complications, it is more serious. Intestinal ulcer is a manifestation of ischemia and ulceration of the intestinal mucosal layer caused by infection, tumor, immunity, etc. Episodes are often accompanied by abdominal pain, diarrhea and other symptoms. This disease is usually not serious if it is treated actively and timely or if the condition is relatively mild. If the intestinal ulcer shows a lot of blood in the stool or has complications such as intestinal stenosis, intestinal perforation, or even causes cancer then it is a serious case. If the duodenal ulcer is caused by Helicobacter pylori infection can be eradicated using a four-pronged approach i.e. one proton pump inhibitor such as omeprazole + one bismuth such as colloidal bismuth + two antibiotics such as amoxicillin and clarithromycin. Bacterial dysentery is mainly treated with antibiotics such as quinolones and azithromycin. For refractory ulcers, ulcers with suspected malignancy, etc., surgery is required, such as radical surgery for colon cancer. If the ulcerative colitis caused by infection and immune abnormality can be treated with aminosalicylic acid preparation, glucocorticoid and other medications according to the situation, and patients with complicated hemorrhage and intestinal perforation need to undergo surgical treatment. Patients with intestinal ulcers should consult a doctor in time to identify the cause of the disease and carry out causative and symptomatic treatment.